Some of these lines you might want to jump on pretty quickly, because they won't be around long.
1. Miami @ New England (-7) [47.5]
Pick: Miami to cover +7
No WAY this line is available by the end of the day, and if you don't lock it in, you're likely to never see it again. New England's roster is a shell of it's former self due to attrition and injuries, and the Dolphins are undefeated and playing good football.
2. Houston @ Indianapolis (-1) 
Pick: Indianapolis to cover -1
I'm continuing to fade Houston as the Texans are a poorly coached mess of a team, one who has never played well in Indianapolis at that. While the Colts are not world beaters, they've looked better this year and I think they win by more than a touchdown.
3. New Orleans (-3.5) @ NY Giants 
Pick: OVER 50
This is not a statement of faith in the Giants offense, but a stand against a Saints defense that hasn't been able to stop a hard charging Jr. High Marching Band over the first 3 weeks. I would play this angle until the books catch on and elevate the lines.
Games in which I have a rooting Interest:
San Francisco @ Los Angeles Chargers(-10.5) [46.5]
There is no hope, only darkness and despair. First Jeremy McKinnon and now Jimmy Garappolo are out for the season with ACL tears. Us 49er faithful turn our eyes to....CJ Betheard.
It's so bad that the team brought in Tom Savage, Tom.Freaking.Savage for a tryout. Fortunately, it looks like sanity prevailed and they're not going to sign him. Fans are calling for Kapernick, Nick Mullens is the current backup, and all is lost.
Good luck and enjoy the games.